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Chemical Structure : TM-5275
CAS No.: 1103926-82-4
Catalog No.: PC-60844Not For Human Use, Lab Use Only.
TM-5275 (TM5275) is a potent, orally active PAI-1 (plasminogen activator inhibitor-1) inhibitor with IC50 of 6.95 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $268 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | $758 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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TM-5275 (TM5275) is a potent, orally active PAI-1 (plasminogen activator inhibitor-1) inhibitor with IC50 of 6.95 uM.
TM-5275 does not interfere with other serpin/serine protease systems (α1-antitrypsin/trypsin and α2-antiplasmin/plasmin).
TM-5275 exhibits antithrombotic effect in an arterial venous shunt thrombosis model (1-10 mg/kg).
TM-5275 blocks TGF-β1-induced lung fibrosis, and induces apoptosis in both myofibroblasts (TGF-β1-treated) and naive (TGF-β1-untreated) human lung fibroblasts.
| M.Wt | 543.98 | |
| Formula | C28H27ClN3NaO5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-[2-[2-(4-Benzhydrylpiperazin-1-yl)-2-oxoethoxy]acetamido]-5-chlorobenzoic acid sodium salt |
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1. Izuhara Y, et al. J Cereb Blood Flow Metab. 2010 May;30(5):904-12.
2. Huang WT, et al. Am J Respir Cell Mol Biol. 2012 Jan;46(1):87-95.
3. Tashiro Y, et al. Blood. 2012 Jun 28;119(26):6382-93.
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