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TMP-153

Chemical Structure TMP-153

CAS No.: 128831-46-9

TMP-153 (TMP153)

Catalog No.: PC-63363Not For Human Use, Lab Use Only.

TMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

TMP-153 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor with IC50 of 5-10 nM for the hepatic and intestinal ACAT from various animals; inhibits cholesterol esterification both in human colonic adenocarcinoma cells, LS180, and in human hepatoma cells, HepG2 (IC50 = 150 nM and 330 nM, respectively); inhibits cholesterol absorption and lowers plasma cholesterol in rats and hamsters.

Hypercholesterolemia

Discontinued

Physicochemical Properties

M.Wt 437.9
Formula C24H18ClF2N3O
CAS No. 128831-46-9
Storage
Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 3 Month
Shipping
Solubility

Chemical Name

N-[4-(2-chlorophenyl)-6,7-dimethyl-3-quinolinyl]-N'-(2,4-difluorophenyl)-urea

Clinical Information

References

1. Sugiyama Y, et al. Atherosclerosis. 1995 Feb;113(1):71-8.

2. Sugiyama Y, et al. Atherosclerosis. 1995 Nov;118(1):145-53.

3. Tawada H, et al. J Med Chem. 1994 Jun 24;37(13):2079-84.

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