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Chemical Structure : TP-0463518
Catalog No.: PC-63449Not For Human Use, Lab Use Only.
TP-0463518 is a novel, highly potent HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 13 nM and 18 nM for human and rat PHD2, respectively.
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TP-0463518 is a novel, highly potent HIF prolyl hydroxylase (PHD) inhibitor with IC50 of 13 nM and 18 nM for human and rat PHD2, respectively; demonstrates to promote the production of erythropoietin (EPO) following oral administration in mice and rats, shows potential for treatment of renal anemia.
| M.Wt | 431.829 | |
| Formula | C20H18ClN3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Hamada M, et al. Bioorg Med Chem Lett. 2018 Apr 16. pii: S0960-894X(18)30351-2.
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