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Chemical Structure : TTI-101
CAS No.: 432001-19-9
Catalog No.: PC-61162Not For Human Use, Lab Use Only.
C188-9 (TTI-101) is a novel small-molecule STAT3 inhibitor with Ki of 12.4 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $228 | In stock | |
| 50 mg | $368 | In stock | |
| 100 mg | $558 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
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C188-9 (TTI-101) is a novel small-molecule STAT3 inhibitor with Ki of 12.4 nM.
C188-9 inhibits STAT3 binding to its pY-peptide ligand, suppresses cytokine-stimulated pSTAT3, reduces constitutive pSTAT3 activity, and inhibits anchorage dependent and independent growth of in multiple HNSCC cell lines.
C188-9 prevents tumor xenograft growth, modulates many STAT3-regulated genes involved in oncogenesis and radioresistance in vivo.
| M.Wt | 471.53 | |
| Formula | C27H21NO5S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(1',2-dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-methoxybenzenesulfonamide |
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1. Redell MS, et al. Blood. 2011 May 26;117(21):5701-9.
2. Bharadwaj U, et al. Oncotarget. 2016 May 3;7(18):26307-30.
3. Jung KH, et al. Clin Cancer Res. 2017 Sep 15;23(18):5537-5546.
4. Minus MB, et al. Angew Chem Int Ed Engl. 2015 Oct 26;54(44):13085-9.
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