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Chemical Structure : Thymidine Phosphorylase inhibitor TPI
CAS No.: 183204-72-0
Catalog No.: PC-35966Not For Human Use, Lab Use Only.
Thymidine Phosphorylase inhibitor TPI (hTP inhibitor TPI) is a potent, selective inhibitor of thymidine phosphorylase (TPase) with Ki of 17 nM, does not inhibits uridine phosphorylase, thymidine kinase, orotate phosphoribosyltransferase, or dihydropyrimidine dehydrogenase.
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|---|---|---|---|
| 25 mg | $198 | In stock | |
| 100 mg | $468 | In stock | |
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Thymidine Phosphorylase inhibitor TPI (hTP inhibitor TPI) is a potent, selective inhibitor of thymidine phosphorylase (TPase) with Ki of 17 nM, does not inhibits uridine phosphorylase, thymidine kinase, orotate phosphoribosyltransferase, or dihydropyrimidine dehydrogenase; oral administration of TPI significantly potentiated the antitumor activity of F(3)dThd on AZ-521 human stomach cancer xenografts in nude mice.
| M.Wt | 279.121 | |
| Formula | C9H12Cl2N4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-chloro-6-((2-iminopyrrolidin-1-yl)methyl)pyrimidine-2,4(1H,3H)-dione hydrochloride |
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1. Fukushima M, et al. Biochem Pharmacol. 2000 May 15;59(10):1227-36.
2. Sperotto N, et al. J Med Chem. 2019 Jan 7. doi: 10.1021/acs.jmedchem.8b01305.
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