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UBX-382

Chemical Structure : UBX-382

CAS No.: 2884554-45-2

UBX-382 (UBX382)

Catalog No.: PC-49392Not For Human Use, Lab Use Only.

UBX-382 (UBX382) is a potent and orally available proteolysis-targeting chimera (PROTAC) that induces potent BTK degradation in DLBCL cell line with DC50 of 4.5 nM.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

UBX-382 (UBX382) is a potent and orally available proteolysis-targeting chimera (PROTAC) that induces potent BTK degradation in DLBCL cell line with DC50 of 4.5 nM.
UBX-382 efficiently inhibits MEK and ERK signaling in B-cell lymphoma.
UBX-382 degrades various mutant BTK proteins in vitro and in vivo, UBX-382 significantly inhibits cell proliferation in cell lines including C481S mutant.
UBX-382 inhibits hematological cell line proliferation via CRBN dependency.

Physicochemical Properties

M.Wt 752.880
Formula C42H44N10O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

5-(4-((7-((3-((2,6-dimethylphenyl)amino)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)-3,4-dihydroisoquinolin-2(1H)-yl)methyl)piperidin-1-yl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

References

1. Ye Seul Lim, et al. Blood Adv. 2022 Oct 21;bloodadvances.2022008121.

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