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Chemical Structure : V-9302
CAS No.: 1855871-76-9
Catalog No.: PC-50008Not For Human Use, Lab Use Only.
V-9302 (V9302) is a competitive, selective antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 with IC50 of 9.6 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 25 mg | $258 | In stock | |
| 50 mg | $458 | In stock | |
| 100 mg | $788 | In stock | |
| 1 g | Get quote |
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V-9302 (V9302) is a competitive, selective antagonist of transmembrane glutamine flux that selectively and potently targets the amino acid transporter ASCT2 with IC50 of 9.6 uM.
V-9302 displays 100-fold improvement in potency over γ-L-glutamyl-p-nitroanilide (GPNA).
V-9302 attenuates cancer cell growth and proliferation (CRC cell lines EC50=9-15 uM), increases cell death, and increases oxidative stress, which collectively contribute to antitumor responses in vitro and in vivo.
| M.Wt | 538.688 | |
| Formula | C34H38N2O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
(S)-2-amino-4-(bis(2-((3-methylbenzyl)oxy)benzyl)amino)butanoic acid |
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1. Schulte ML, et al. Nat Med. 2018 Jan 15. doi: 10.1038/nm.4464.
2. Schulte ML, et al. Bioorg Med Chem Lett. 2016 Feb 1;26(3):1044-1047.
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