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Cat. No. Product Name Information
PC-20248

NV-6297

GLUT-1 inhibitor

NV-6297 (NV6297) is a potent, selective mTORC1 pathway signaling inhibitor without inhibition on mTORC2, inhibits S6K1 phosphorylation (pS6K1 T389) in MCF7 cells with IC50 of 120 nM, directly and selectively targets GLUT-1.
PC-20247

NV-5440

GLUT-1 inhibitor, mTORC1 inhibitor

NV-5440 (NV5440) is a potent, selective mTORC1 pathway signaling inhibitor without inhibition on mTORC2, inhibits S6K1 phosphorylation (pS6K1 T389) in MCF7 cells with IC50 of 70 nM, directly targets GLUT-1 with Ki of 69.3 nM.
PC-49856

GTS467

EAAT2 activator

GTS476 (GTS-476) is a potent, selective, orally active activator of EAAT2 with EC50 of 35.1 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2.
PC-49855

GT949

EAAT2 activator

GT949 (GT-949) is a potent, selective activator (positive allosteric modulator) of EAAT2 with EC50 of 0.26 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2.
PC-49854

GTS511

EAAT2 activator

GTS511 (GTS-511) is a potent, selective, brain-permeable activator of EAAT2 with EC50 of 3.8 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2.
PC-49853

GT951

EAAT2 activator

GT951 (GT-951) is a potent, selective activator (positive allosteric modulator) of EAAT2 with EC50 of 0.8 nM in vitro glutamate uptake assays in COS cells overexpressing EAAT2.
PC-49277

(R)-AS-1

EAAT2 PAM

(R)-AS-1 is an orally bioavailable, selective positive allosteric modulator (PAM) of the glutamate transporter EAAT2 with EC50 of 11 nM and Emax of 251%, shows potent antiseizure activity in vivo.
PC-72279

MC-100093

GLT-1 modulator

MC-100093 (MC100093) is a potent, orally bioavailable upregulator of glutamate transporter-1 (GLT-1) and devoid of antimicrobial properties.
PC-36103

Troriluzole

Glutamate modulator

Trigriluzole (BHV-4157) is a novel glutamate modulator for the treatment of mild-to-moderate Alzheimer’s disease (AD).
PC-35512

WAY-213613

EAAT2 inhibitor

WAY-213613 (WAY213613) is a potent, non-substrate inhibitor of EAAT2 (GLT-1) with IC50 of 85 nM, displays > 44-fold selectivity over EAAT1 and EAAT3.
PC-35511

NBI-59159

EAAT3 inhibitor

NBI-59159 (NBI59159) is a potent EAAT3-preferring inhibitor.
PC-62149

UCPH-102

EAAT1 inhibitor

UCPH-102 is a selective, brain penetrant inhibitor of EAAT1 (Excitatory amino acid transporter 1) with IC50 of 420 nM.

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