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Chemical Structure : VCP Activator 1
Catalog No.: PC-21286Not For Human Use, Lab Use Only.
VCP Activator 1 (VA1) is a small molecule allosteric activator of valosin-containing protein (VCP)/p97, dose-dependently stimulates VCP ATPase activity up to 3-fold (EC50= 4 uM).
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VCP Activator 1 (VA1) is a small molecule allosteric activator of valosin-containing protein (VCP)/p97, dose-dependently stimulates VCP ATPase activity up to 3-fold (EC50= 4 uM).
VCP Activator 1 (VA1) binds in an allosteric pocket near the VCP D2 ATP-binding site in both the apo and ADP-bound states.
VCP Activator 1 (VA1) direct interactions with VCP with ITC KD of 27 uM.
| M.Wt | 354.47 | |
| Formula | C20H22N2O2S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. N H Jones, et al. bioRxiv. 2023 Oct 2:2023.10.02.560478.
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