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Chemical Structure : VPC-18005
Catalog No.: PC-61463Not For Human Use, Lab Use Only.
VPC-18005 (VPC18005) is a novel small molecule ERG (ETS-related gene) antagonist that inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, disrupts the ERG binding to DNA (Kd=250 uM).
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VPC-18005 (VPC18005) is a novel small molecule ERG (ETS-related gene) antagonist that inhibits ERG-induced transcription and interacts directly with the ERG-ETS domain, disrupts the ERG binding to DNA (Kd=250 uM); markedly decreases SOX9 expression, inhibits migration and invasion of ERG-overexpressing prostate cancer cells in vitro, and reduces metastasis in a zebrafish xenograft model.
| M.Wt | 319.379 | |
| Formula | C15H17N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Butler MS, et al. Oncotarget. 2017 Jun 27;8(26):42438-42454.
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