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Chemical Structure : VR-23
CAS No.: 1624602-30-7
Catalog No.: PC-45547Not For Human Use, Lab Use Only.
A potent inhibitor of trypsin-like proteasome (IC50=1 nM), chymotrypsin-like proteasome (IC50=50-100 nM) and caspase-like proteasome (IC50=3 uM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $160 | In stock | |
| 50 mg | $600 | In stock | |
| 100 mg | $960 | In stock |
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A potent inhibitor of trypsin-like proteasome (IC50=1 nM), chymotrypsin-like proteasome (IC50=50-100 nM) and caspase-like proteasome (IC50=3 uM); targets the β2 of the 20S proteasome catalytic subunit and structurally distinct from other known proteasome inhibitors and selectively kills cancer cells by apoptosis, with little effect on noncancerous cells.
| M.Wt | 477.8782 | |
| Formula | C19H16ClN5O6S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Quinoline, 7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]- |
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1. Pundir S, et al. Cancer Res. 2015 Oct 1;75(19):4164-75.
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