Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : Vaniprevir
CAS No.: 923590-37-8
Catalog No.: PC-42481Not For Human Use, Lab Use Only.
A potent, selective, orally available inhibitor of HCV NS3/4A protease with Ki of 0.05 and 0.9 nM for GT1b and 2a protease, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $400 | In stock | |
| 50 mg | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
A potent, selective, orally available inhibitor of HCV NS3/4A protease with Ki of 0.05 and 0.9 nM for GT1b and 2a protease, respectively; displays excellent selectivity against both a range of human proteases and a broad panel of pharmacologically relevant targets; has replicon EC50 of 3 and 9 nM for GT1b and 2a, respectively, has good plasma exposure and excellent liver exposure in multiple species.
HCV Infection
Approved
| M.Wt | 757.9364 | |
| Formula | C38H55N5O9S | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Cyclopropanecarboxamide, N-[[[6-(2-carboxy-2,3-dihydro-1H-isoindol-4-yl)-2,2-dimethylhexyl]oxy]carbonyl]-3-methyl-L-valyl-(4R)-4-hydroxy-L-prolyl-1-amino-N-(cyclopropylsulfonyl)-2-ethyl-, (12)-lactone, (1R,2R)- |
|
1. McCauley JA, et al. J Med Chem. 2010 Mar 25;53(6):2443-63.
2. Liverton NJ, et al. Antimicrob Agents Chemother. 2010 Jan;54(1):305-11.
3. Manns MP, et al. Hepatology. 2012 Sep;56(3):884-93.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
