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Chemical Structure : WEB-2086
Catalog No.: PC-70045Not For Human Use, Lab Use Only.
A potent and specific antagonist of platelet activating factor (PAF) receptor that inhibits PAF-induced human platelet and neutrophil aggregation in vitro with IC50 of 0.17 and 0.36 uM, respectively.
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A potent and specific antagonist of platelet activating factor (PAF) receptor that inhibits PAF-induced human platelet and neutrophil aggregation in vitro with IC50 of 0.17 and 0.36 uM, respectively; reverses or abolishes the bronchoconstriction, hypotension, thrombocytopenia and leukopenia induced by PAF-acether at 0.1-1 mg/kg in guinea-pigs; also markedly decreases the bronchoconstriction and leukopenia induced by 100 ug/kg antigen in mepyramine.
| M.Wt | 455.961 | |
| Formula | C22H22N5O2SCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Casals-Stenzel J, et al. J Pharmacol Exp Ther. 1987 Jun;241(3):974-81.
2. Casals-Stenzel J, et al. Br J Pharmacol. 1987 Aug;91(4):799-802.
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