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Chemical Structure : XL-999
Catalog No.: PC-63212Not For Human Use, Lab Use Only.
XL-999 is a potent, multi-targeted receptor tyrosine kinases (RTKs) inhibitor with IC50 of 2.6, 8.2, 1.5 and 0.8 nM for VEGFR-2, FGFR-1, PDGFRβ and FLT-3, respectively.
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XL-999 is a potent, multi-targeted receptor tyrosine kinases (RTKs) inhibitor with IC50 of 2.6, 8.2, 1.5 and 0.8 nM for VEGFR-2, FGFR-1, PDGFRβ and FLT-3, respectively; also potently inhibits Axl, Kit and Flt-4; does not block c-Met but does block many other targets of XL880 and XL184, reduces the vascularity of RIP-Tag2 tumors.
| M.Wt | 445.542 | |
| Formula | C26H28FN5O | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. You WK, et al. Cancer Res. 2011 Jul 15;71(14):4758-68.
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