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YK5

Chemical Structure : YK5

CAS No.: 1268273-23-9

YK5

Catalog No.: PC-62469Not For Human Use, Lab Use Only.

YK5 is a small molecule inhibitor of Hsp70 and Hsc70, induces the degradation of HER2, Raf-1, and Akt kinases, also induces apoptosis in the SKBr3 breast cancer cells..

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

YK5 is a small molecule inhibitor of Hsp70 and Hsc70, induces the degradation of HER2, Raf-1, and Akt kinases, also induces apoptosis in the SKBr3 breast cancer cells.

Physicochemical Properties

M.Wt 432.503
Formula C18H24N8O3S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N-(6-amino-2-((4,6-dimethoxy-2-(4-methylpiperazin-1-yl)pyrimidin-5-yl)thio)pyrimidin-4-yl)acrylamide

References

1. Rodina A, et al. Chem Biol. 2013 Dec 19;20(12):1469-80.

2. Rodina A, et al. Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL

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