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Chemical Structure : ZM39923
CAS No.: 273727-89-2
Catalog No.: PC-43113Not For Human Use, Lab Use Only.
ZM39923 is a potent, selective JAK3 inhibitor with pIC50 of 7.1, also potently inhibits human tissue transglutaminase (TGM2, hTG2) with IC50 of 10 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $98 | In stock | |
| 50 mg | $268 | In stock | |
| 100 mg | $468 | In stock | |
| 250 mg | Get quote | ||
| 1 g | Get quote |
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ZM39923 is a potent, selective JAK3 inhibitor with pIC50 of 7.1, also potently inhibits human tissue transglutaminase (TGM2, hTG2) with IC50 of 10 nM.
ZM39923 is less potent for EGFR, JAK1 and CDK4 with pIC50 of 5.6, 4.4 and < 5.0, no activity fgor JAK2.
ZM39923 alteres TGM2 activity in polyglutamine-expressing Drosophila model of neurodegeneration and is found to improve survival.
ZM39923 significantly attenuates CCR7-induced Jak3 phosphorylation in metastatic SCCHN cells.
| M.Wt | 331.4507 | |
| Formula | C23H25NO | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
1-Propanone, 3-[(1-methylethyl)(phenylmethyl)amino]-1-(2-naphthalenyl)- |
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1. Lai TS, et al. Chem Biol. 2008 Sep 22;15(9):969-78.
2. Zhang Z, et al. Oncol Lett. 2017 May;13(5):3191-3197.
3. Luo C, et al. Drug Discov Today. 2004 Mar 15;9(6):268-75.
4. Brown GR, et al. Bioorg Med Chem Lett. 2000 Mar 20;10(6):575-9.
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