ZN-c3 | Wee1 inhibitor | Probechem Biochemicals

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Chemical Structure : ZN-c3

ZN-c3 (Azenosertib, Wee1 inhibitor ZN-c3)

Catalog No.: PC-72320Not For Human Use, Lab Use Only.

Azenosertib (ZN-c3, Wee1 inhibitor ZN-c33) is a highly potent, selective Wee1 inhibitor with IC50 of 3.8 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

Azenosertib (ZN-c3, Wee1 inhibitor ZN-c33) is a highly potent, selective Wee1 inhibitor with IC50 of 3.8 nM.
ZN-c3 showed excellent in vivo efficacy and is currently being evaluated in phase 2 clinical trials.

Physicochemical Properties

M.Wt	526.645
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-allyl-1-(7-ethyl-7-hydroxy-6,7-dihydro-5H-cyclopenta[b]pyridin-2-yl)-6-((4-(4-methylpiperazin-1-yl)phenyl)amino)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one

References

1. Peter Q Huang, et al. J Med Chem. 2021 Sep 9;64(17):13004-13024.

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ZN-c3 (Azenosertib, Wee1 inhibitor ZN-c3)

Biological Activity

Physicochemical Properties

References

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