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Chemical Structure : Zegocractin
CAS No.: 1713240-67-5
Catalog No.: PC-38432Not For Human Use, Lab Use Only.
Zegocractin (CM4620) is a selective small molecule Orai1 channel inhibitor, inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of 120 nM and 900 nM, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $248 | In stock | |
| 25 mg | $428 | In stock | |
| 50 mg | $728 | In stock | |
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| 250 mg | Get quote | ||
| 1 g | Get quote |
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Zegocractin (CM4620) is a selective small molecule Orai1 channel inhibitor, inhibits Orai1/STIM1-mediated Ca2+ currents and Orai2/STIM1-mediated currents with IC50 of 120 nM and 900 nM, respectively.
CM4620 efficiently blocks store-operated Ca2+ entry (SOCE) in pancreatic acinar cells.
CM4620 prevents cell death and trypsinogen activation in primary rodent and human acini.
CM4620 administration (20 mg/kg) significantly reduces pancreatitis responses in mouse cerulein acute pancreatitis.
CM4620 inhibits CCK-induced NFAT and NF-κB activities in pancreatic acinar cells, inhibits cytokine production in PBMCs (IC50, 47 to 952 nM) and reduces oxidative burst in neutrophils.
| M.Wt | 421.760 | |
| Formula | C19H11ClF3N3O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-(5-(6-chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)pyrazin-2-yl)-2-fluoro-6-methylbenzamide |
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1. Waldron RT, et al. J Physiol. 2019 Jun;597(12):3085-3105.
2. Uchimura T, et al. Biomedicines. 2021 Oct 31;9(11):1589.
3. Gerasimenko JV, et al. Function (Oxf). 2022 Jan 31;3(2):zqac002.
4. Wen L, et al. Gastroenterology 149, 481-92.e7.
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