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Cat. No. Product Name CAS No. Information
PC-63453

A4250

501692-44-0

A4250 (A-4250, Odevixibat) is a small molecule ileal bile acid transporter (IBAT) inhibitor for the treatment of cholestatic liver diseases including progressive familial intrahepatic cholestasis and NASH.

Other Indication

Phase 3 Clinical

PC-63549

Lopixibat chloride

228113-66-4 Lopixibat chloride (LUM-001, HP-625) is a potent, selectiove, oral inhibitor of sodium bile acid cotransporter and Ileal bile acid transporter (IBAT).

Hypercholesterolemia

Phase 2 Clinical

PC-61419

Volixibat potassium

1431935-92-0 A highly potent and selective inhibitor of the apical sodium-dependent bile acid transporter (ASBT) in development for the treatment of nonalcoholic steatohepatitis (NASH).

Steatohepatitis

Phase 2 Clinical

PC-61418

Volixibat

1025216-57-2 A highly potent and selective inhibitor of the apical sodium-dependent bile acid transporter (ASBT) in development for the treatment of nonalcoholic steatohepatitis (NASH).

Steatohepatitis

Phase 2 Clinical

PC-61407

Elobixibat

439087-18-0 An orally available, potent and selective ileal bile acid transporter (IBAT) inhibitor for the treatment of constipation.

Other Indication

Phase 2 Clinical

PC-61384

Linerixibat

1345982-69-5 A highly potent, selective, ileal apical sodium-dependent bile acid transporter (ASBT) inhibitor with IC50 of 2.1/1.9 nM for mouse/rat ASBT, respectively; lowers glucose in an animal model of type 2 diabetes, shows excellent developability properties for evaluating the potential therapeutic utility of a nonabsorbable ASBT inhibitor for treatment of patients with type 2 diabetes.

Diabetes

Phase 2 Clinical

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