| Cat. No. |
Product Name |
Information |
| PC-23920 |
BDM_92499
IRAP inhibitor
|
BDM_92499 is a potent, selective inhibitor of insulin-regulated aminopeptidase IRAP with IC50 of 3.4 nM has >150-fold selecive\ity over ERAP1 and ARAP2. |
| PC-23105 |
CQ80
PEPD/XPNPEP1 inhibitor
|
CQ80 is a dual inhibitor of the Xaa-Pro-cleaving M24B aminopeptidases PEPD and XPNPEP1 with IC50 of 0.91 and 43 uM respectively, selectively activates the CARD8 inflammasome. |
| PC-23036 |
QGC583
Aminopeptidase A inhibitor
|
QGC583 is a potent, selective aminopeptidase A (APA) with IC50 of 4 nM, >5000-fold selective over aminopeptidase N (APN). |
| PC-22853 |
Carnosic acid
ERAP1 inhibitor
|
Carnosic acid is a highly selective inhibitor targeting the orthosteric site of ERAP1 with IC50 of 10.73 uM, inhibits oxidative stress and inflammation, suppressescell proliferation, and has antibacterial activity. |
| PC-22787 |
Fumagillin
MetAP2 inhibitor
|
Fumagillin (NSC9168) is an antimicrobial compound that covalently binds and inhibits the methionine aminopeptidase MetAP-2, inhibits angiogenesis and cancer cell proliferation. |
| PC-22329 |
SDX-7539
MetAP2 inhibitor
|
SDX-7539 is a potent and selective METAP2 inhibitor. |
| PC-22166 |
QHL1
IRAP inhibitor
|
QHL1 is a potent, selective insulin-regulated aminopeptidase (IRAP) inhibitor with IC50 of 320 nM. |
| PC-21697 |
HFI-419
IRAP inhibitor
|
HFI-419 is a specifc inhibits of insulin-regulated aminopeptidase (IRAP) with Ki of 0.48 uM, potent inhibits the hydrolysis of the dipeptidic substrate L-Leucine-7-amido-4-methylcoumarin with IC50 of 0.4 uM, >1000-fold lower or no affinity for related and unrelated enzymes. |
| PC-20620 |
Actinonin
Aminopeptidase M inhibitor.
|
Actinonin is an isolated antibiotic and shown to be an inhibitor of aminopeptidase M, inhibits enkephalin-degrading enzymes from guinea-pig striatum (enkephalin-aminopeptidase), striatal membrane neutral endopeptidase and soluble dipeptidylaminopeptidase in rat whole brain homogenate with IC50 of 0.39, 5.6 and 1.1 uM, respectively. |
| PC-61442 |
Beloranib hemioxalate
|
An analog of the natural compound Fumagillin that functions as a highly potent methionine aminopeptidase 2 (MetAP2) inhibitor. |
