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Leonurine (SCM-198) is a natural alkaloid that exhibits cardio-and neuronal-protective effects both in vitro and in vivo, occupies the caspase recruitment site of Apaf-1, blocks its interaction with procaspase-9; attenuates doxorubicin-induced apoptosis in H9c2 cardiac muscle cells, protects middle cerebral artery occluded rats through antioxidant effect and regulation of mitochondrial function, attenuates myocardial fibrotic response via inhibition of NADPH oxidase 4 (Nox4).



1470302-79-4 ZYZ-488 is a novel inhibitor of apoptotic protease activating factor-1 (Apaf-1), inhibits the activation of binding protein procaspase-9 and procaspase-3; exhibits cardioprotective effects on hypoxia-induced H9c2 rat ventricular cells, decreased apoptosis in hypoxic H9c2 cells, shows potential for treating cardiac ischemia.

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