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Cat. No. Product Name CAS No. Information
PC-45829

AT-9283

896466-04-9 A multi-targeted kinase inhibitor with potent activity against Aurora A, Aurora B, JAK2, JAK3, and ABL (T315I) with IC50 of 3, 3, 1.2, 1.1, and 4 nM, respectively; also inhibits GSK-3β, FGFR2, VEGFR3, Mer, etc. (IC50=1-10 nM); potently inhibits proliferation and Jak2-related signalling in Jak2-dependent cell lines, demonstrates significant therapeutic potential in vivo in an ETV6-JAK2 (TEL-JAK2) murine leukaemia model.

Blood Cancer

Phase 2 Clinical

PC-42766

ENMD-2076

934353-76-1 A multitargeted kinase inhibitor with IC50s of 3/14/23/40 nM for Flt3/Aurora A/Src/VEGFR2; also inhibits Aurora B, c-Kit, FGFR1 (IC50=100-350 nM); orally bioactive.
PC-42765

ENMD-2076 tartrate

1291074-87-7 A multitargeted kinase inhibitor with IC50s of 3/14/23/40 nM for Flt3/Aurora A/Src/VEGFR2; also inhibits Aurora B, c-Kit, FGFR1 (IC50=100-350 nM); orally bioactive.

Liver Cancer

Phase 2 Clinical

PC-42912

TAK-901

934541-31-8 A multikinase inhibitor with IC50 of 21 nM and 15 nM for Aurora A/TPX2 and Aurora B/INCENP respectively; inhibits 56 kinases(IC50< 100 nM); inhibits kinds of cancer cell lines with EC50s of 40-500 nM; suppresses cellular histone H3 phosphorylation and induced polyploidy.

Blood Cancer

Phase 1 Discontinued

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