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Cat. No. Product Name CAS No. Information
PC-35253

Ubrogepant

1374248-77-7 Ubrogepant (MK-1602) is a novel potent, selective, oral calcitonin gene-related peptide receptor (CGRP) antagonist for acute treatment of migraine.

Migraine

Phase 3 Clinical

PC-62994

MK-8825

1380887-60-4 MK-8825 is a highly potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 17 nM for rat CGRP; blocks hCGRP-stimulated cAMP responses in HEK293 cells stably expressing the human CGRP receptor with IC50 of 0.23 nM; possesses significantly improved in vivo potency in rat pharmacodynamic models.

Migraine

Phase 1 Clinical

PC-60031

Atogepant

1374248-81-3 A potent, selective and orally available CGRP receptor antagonist for the prevention of migraine.

Migraine

Phase 3 Clinical

PC-42296

Olcegepant (hydrochloride)

586368-06-1 The first small molecule selective CGRP antagonist with Ki of 14.4 nM for hCGRP; inhibits the effects of CGRP, released by stimulation of the trigeminal ganglion, on facial blood flow in marmoset monkeys (1-30mg/kg, i.v.).
PC-42294

Olcegepant

204697-65-4 The first small molecule selective CGRP antagonist with Ki of 14.4 nM for hCGRP; inhibits the effects of CGRP, released by stimulation of the trigeminal ganglion, on facial blood flow in marmoset monkeys (1-30mg/kg, i.v.).
PC-45811

MK-0974

781649-09-0 A potent, selective, orally bioavailable CGRP receptor antagonist with Ki of 0.77 nM; shows >10,000-fold selectivity in a panel of assays representing over 160 receptors, transporters, and enzymes; inhibits CGRP-stimulated cAMP production in E10 cells with IC50 of 2.2 nM; inhibits the capsaicin-induced increase in dermal blood flow in monkey models.

Migraine

Phase 3 Discontinued

PC-42517

MK-3207 (Hydrochloride)

957116-20-0 A highly potent, selective CGRP receptor antagonist with Ki of 21 pM in in vitro binding assay and IC50 of 0.12 nM in cell-based functional assay; displays >50000-fold selectivity in a panel of 160 enzymes, receptors, channels, and 65-fold more potent than telcagepant; orally bioavailable.

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