Cat. No. |
Product Name |
Information |
PC-21433 |
CLK1 inhibitor 25
CLK inhibitor
|
CLK1 inhibitor 25 is a potent and selective inhibitor of cdc2-like kinase 1 (CLK1) with IC50 of 2 nM, 69-fold selective over DYRK1A. |
PC-21432 |
SGC-CLK-1N
CLK inhibitor
|
SGC-CLK-1N (CAF-225) is the negative control compound of CLK1/2/4 inhibitor SGC-CLK-1 (CAF-170). |
PC-21431 |
SGC-CLK-1
CLK inhibitor
|
SGC-CLK-1 (CAF-170) is a potent and selective inhibitor of Cdc2-Like kinases CLK1, 2 and 4 with binding IC50 values of 13 nM, 4 nM, and 46 nM, resepctively. |
PC-20985 |
Leucettinib-92
DYRK/CLK inhibitor
|
Leucettinib-92 is a potent DYRK/CLK inhibitor, inhibits CLK1, CLK2, CLK4, DYRK1A and DYRK1B with IC50 of 9.2, 6, 6, 1.2 and 1.8 nM, respectively. |
PC-20895 |
MW01
CLK inhibitor
|
MW01 is a specific inhibitor for DNA damage-induced NF-κB activity, inhibits CLK2 and CLK4 with IC50 of 360 and 14.1 nM, does not inhibit CLK3. |
PC-20894 |
MW05
CLK inhibitor
|
MW05 is a specific inhibitor for DNA damage-induced NF-κB activity, inhibits CLK2 and CLK4 with IC50 of 1400 and 307 nM, does not inhibit CLK3. |
PC-20756 |
ML315
CLK inhibitor
|
ML315 is a small molecule inhibitor of the cdc2-like (Clk) and dual specificity tyrosine phosphorylation-regulated (Dyrk) kinases with IC50 of 68, 231, >10,000, 68, 282 and 1156 nM for CLK1/2/3/4 and DYRK1/2, respectively. |
PC-20474 |
GPS192
CLK inhibitor
|
GPS192 (GPS 167) is a specific small molecule splicing regulator SRSF10 inhibitor, modulates BCLAF1 splicing with IC50 of 2 uM in human colorectal HCT116 cells, directly inhibits CLK1, CLK2 and CLK4, but not SRPK1 and DYRK1A. |
PC-73374 |
CLK4 inhibitor 96
CLK4 inhibitor
|
CLK4 inhibitor 96 is a novel potent CLK4 inhibitor with IC50 of 57.5 nM. |