Chloride Channel (inhibitors, antagonists, agonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-24829	NPPB Chloride channel blocker	NPPB is a nonspecific chloride channel blocker, inhibits outward rectifying chloride currents (ORCC), suppresses glioma cell migration and invasion.
PC-23883	TMEM16A activator F(act) TMEM16A potentiator	TMEM16A activator F(act) (Fact) is a potent small molecule potentiator of calcium-activated chloride channel TMEM16A (ANO1) with EC50 of 6 uM.
PC-23882	TMEM16A activator E(act) TMEM16A activator	TMEM16A activator E(act) (Eact) is a small molecule activator of calcium-activated chloride channel TMEM16A (ANO1) with EC50 of 3 uM.
PC-23810	Tamsulosin TMEM16A inhibitor	Tamsulosin ((R)-(-)-YM12617 free base) is an inhibitor of α1-adrenergic receptor, also demonstrates significant antiosteoporotic effects by inhibiting calcium-activated chloride channel TMEM16A.
PC-23489	ClC-1 inhibitor Compound A-3 ClC-1 channel inhibitor	ClC-1 inhibitor Compound A-3 is a specific inhibitor of skeletal muscle-specific chloride ion (Cl-) channel ClC-1 with IC50 of 2.3 uM for reduction in the Cl- driven membrane conductance (Gm).
PC-22008	NMD670 sodium ClC-1 inhibitor	NMD670 (NMD-670) sodium salt is a potent, specific and orally bioavailable ClC-1 chloride channel inhibitor with EC50 of 1.6 uM, restores muscle function in rat models of myasthenia gravis (MG).

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