| Cat. No. |
Product Name |
Information |
| PC-72247 |
DNMT3B inhibitor 33h
DNMT3B inhibitor
|
DNMT3B inhibitor 33h is a selective, small molecule inhibitor of DNMT3B with IC50 of 4.8 uM in DRONE assays. |
| PC-72245 |
GSK3484862
DNMT1 inhibitor
|
GSK3484862 (GSK-3484862) is a selective, non-covalent inhibitor of DNMT1, potently inhibits DNMT1 enzymatic activity with IC50 of 0.23 uM. |
| PC-72244 |
GSK3685032
DNMT1 inhibitor
|
GSK3685032 (GSK-3685032) is a potent, first-in-class, highly selective DNMT1 inhibitor with IC50 of 36 nM, >2,500-fold over DNMT3A/3L and DNMT3B/3L. |
| PC-38285 |
STM2457
METTL3 inhibitor
|
STM2457 (STM-2457) is a highly potent, selective first-in-class catalytic inhibitor of METTL3 with IC50 of 16.9 nM, binds to the METTL3-METTL14 with Kd of 1.4 nM. |
| PC-36114 |
Bobcat339
TET inhibitor
|
Bobcat339 (Bobcat 339) is a novel cytosine-based TET enzyme inhibitor with IC50 of 33 uM (TET1) and 73 uM (TET2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a. |
| PC-35290 |
MC3343
DNMT inhibitor
|
MC3343 (MC-3343) is a novel potent, non-nucleoside DNA methyltransferase (DNMT) inhibitor with IC50 of 5.7 and 1.7 uM for DNMT1 and DNMT3a in cell-free assays, respectively. |
| PC-35122 |
NV03
UHRF1 inhibitor
|
NV03 is a small-molecule antagonist of the H3K9me3 binding to UHRF1 tandem tudor domain with Kd of 2.4 uM. |
| PC-35121 |
NV01
UHRF1 inhibitor
|
NV01 is a small-molecule antagonist of the H3K9me3 binding to UHRF1 tandem tudor domain (TTD) with Kd of 5 uM. |
| PC-43175 |
DC-517
DNMT1 inhibitor
|
DC-517 is a potent, selective, non-nucleoside DNA methyltransferase DNMT1 inhibitor with IC50 of 1.7 uM, displays significant selectivity toward other AdoMet-dependent protein methyltransferases. |
| PC-43174 |
DC_05
DNMT1 inhibitor
|
DC_05 is a selective, non-nucleoside DNA methyltransferase DNMT1 inhibitor with IC50 of 10.3 uM, displays 3.6-fold selectivity over PRMT1 and >15-fold over DNMT3A, DNMT3B, G9a, SUV39H1, MLL1, SET7/9.. |
| PC-61160 |
AA-CW236
MGMT inhibitor
|
AA-CW236 is a potent, selective, non-pseudosubstrate inhibitor of O(6) -alkylguanine DNA methyltransferase (MGMT) with low-nanomolar potency. |
| PC-60765 |
SGI-110
DNMT inhibitor
|
SGI-110 (Guadecitabine) is a novel DNA hypomethylating dinucleotide that inhibits DNA methyltransferase (DNMT). |
