| Cat. No. |
Product Name |
Information |
| PC-24929 |
RBBP7 ligand Ynamide YE-1
RBBP7 ligand
|
RBBP7 ligand Ynamide is a novel covalent, electrophilic warhead and ligand of retinoblastoma binding protein 7 (RBBP7) E3 ligase, facilitating the development of PROTAC degraders targeting a wide range of proteins, including CDK4, PDE5, PI3K, AKT, BCR-ABL, BRD4, EGFRL858R, and EGFRL858R/T790M/C797S. |
| PC-24556 |
RR-11055
Cereblon ligand
|
RR-11055 is a potent and novel cereblon (CRBN) ligand with binding IC50 of 0.38 uM, is useful for the development efficacious PROTAC degrader. |
| PC-23383 |
(S)-ACE-OH
TRIM21 molecular glue
|
(S)-ACE-OH is a metabolite of acepromazin, acts as a molecular glue to induce an interaction between the E3 ubiquitin ligase TRIM21 and the nucleoporin NUP98, leading to the degradation of nuclear pore proteins and disruption of nucleocytoplasmic trafficking. |
| PC-22818 |
KDRLKZ-3
|
KDRLKZ-3 is a negative control compound of KDRLKZ-1 and KDRLKZ-2 without affinity for E3 ligase KLHDC2. |
| PC-22817 |
KDRLKZ-2
KLHDC2 ligand
|
KDRLKZ-2 is a small-molecule ligand targeting the E3 ligase KLHDC2 with SPR Kd of 0.095 uM, dosplaces the SelK peptide with IC50 of 0.068 uM as measured by alphaLISA. |
| PC-22816 |
KDRLKZ-1
KLHDC2 ligand
|
KDRLKZ-1 is a small-molecule ligand targeting the E3 ligase KLHDC2 with SPR Kd of 0.36 uM, dosplaces the SelK peptide with IC50 of 0.21 uM as measured by alphaLISA. |
| PC-22414 |
HL389
CRL4 DCAF11 ligand
|
HL389 is a molecular glue acting as recruitment moiety for CRL4 DCAF11 and could be used for developed alkenyl oxindole-based PROTAC molecules. |
| PC-21634 |
Cbl-b inhibitor 3
Cbl-b inhibitor
|
Cbl-b inhibitor 3 is a potent, selective inhibitor of RING finger E3 ligase Cbl-b with IC50 of 5.5 nM in Cbl-b LCK Ub TR-FRET assays. |
| PC-21633 |
Cbl-b inhibitor 2
Cbl-b inhibitor
|
Cbl-b inhibitor 2 is a potent, selective inhibitor of RING finger E3 ligase Cbl-b. |
| PC-21632 |
Cbl-b inhibitor 1
Cbl-b inhibitor
|
Cbl-b inhibitor 1 is a potent, selective inhibitor of RING finger E3 ligase Cbl-b. |
| PC-21631 |
Cbl-b inhibitor 25
Cbl-b inhibitor
|
Cbl-b inhibitor 25 is a potent, selective inhibitor of RING finger E3 ligase Cbl-b with IC50 of 15 nM in TR-FRET assays. |
| PC-21046 |
KLHDC2 E3 ubiquitin ligase ligand 1
KLHDC2 E3 ligand
|
KLHDC2 E3 ubiquitin ligase ligand 1 is a 7 aa C-terminal fragment of the SelK protein used for PROTAC degradation. |
