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Cat. No. Product Name Information
PC-42089

RSL-3

GPX4 inhibitor

GPX4 inhibitor RSL3 is an oncogenic RAS-selective lethal compound that actvates iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells, inhibits glutathione peroxidase (GPX4) and induces ferroptosis in BJeLR cells (EC50=10 nM).
PC-42286

Piperazine Erastin

Ferroptosis inducer

Piperazine Erastin is an analog of Erastin, which can induces ferroptosis in cancer cells, an iron-dependent form of nonapoptotic cell death..
PC-21713

GPX4 inhibitor A16

GPX4 inhibitor

GPX4 inhibitor A16 is a potent, selective and covalent inhibitor of glutathione peroxidase 4 (GPX4), shows potent anti-proliferation activity the pancreatic cancer cell line AsPC-1 with IC50 of 22 nM.
PC-20924

FerroLOXIN-2

Ferroptosis inhibitor

FerroLOXIN-2 is a specific, small-molecule inhibitor of ferroptosis, inhibits 15LOX/PEBP1 catalytic complex rather than 15LOX alone, effectively suppresses ferroptosis in vitro and in vivo.
PC-20923

FerroLOXIN-1

Ferroptosis inhibitor

FerroLOXIN-1 is a specific, small-molecule inhibitor of ferroptosis, inhibits 15LOX/PEBP1 catalytic complex rather than 15LOX alone, effectively suppresses ferroptosis in vitro and in vivo.
PC-20811

FSEN1

FSP1 inhibitor

FSEN1 (Ferroptosis Sensitizer 1) is a specific small molecule, uncompetitive inhibitor of ferroptosis suppressor protein 1 (FSP1) with IC50 of 133 nM, sensitizes cancer cells to ferroptosis.
PC-20810

AKI-02

Ferroptosis inhibitor

AKI-02 is a hydroxypyridinone-based iron chelator, potently inhibits labile iron-mediated ferroptosis.
PC-20267

GPX4 inhibitor 24

GPX4 inhibitor 24 is a potent glutathione peroxidase 4 (GPX4) inhibitor, induces ferroptosis in vivo.
PC-49542

LOC1886

GPX4 inhibitor

LOC1886 is a small molecule allosteric inhibitor of GPX4, inhibits enzymatic activity of GPX4 in HT1080 cell lysates with Ki of 102 uM, degrades GPX4 to induce ferroptosis, binds covalently to C66 of GPX4.

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