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N/A A small molecule, selective FOXO1 inhibitor that inhibits FOXO-dependent glucose production devoid of lipogenic activity in hepatocytes; shows beneficial effects of FOXO1 inhibition on diabetic hyperglycemia by reducing hepatic glucose production.


836620-48-5 A novel transcription factor Foxo1 inhibitor that potently and selectively inhibits Foxo1-mediated transactivation with IC50 of 33 nM, with no significant activity on Foxo3a and Foxo4; reduces glucose production through the inhibition of G6pase and phosphoenolpyruvate carboxykinase (PEPCK) mRNA levels in a rat hepatic cell line; decreases fasting plasma glucose level in diabetic db/db mice.

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