| Cat. No. |
Product Name |
Information |
| PC-49825 |
AZD6370
Glucokinase activator
|
AZD6370 (AZD-6370) is a potent, selective and orally active glucokinase (GK) activator with EC50 of 45 nM against human recombinant GK. |
| PC-49824 |
AZD1656
Glucokinase activator
|
AZD1656 (AZD-1656) is a potent, selective and orally active glucokinase (GK) activator with EC50 of 57 and 72 nM for human and rat GK, respectively. |
| PC-35647 |
Sinogliatin
|
Sinogliatin (Dorzagliatin, HMS-5552, RO-5305552) is a novel, first-in-class glucokinase activator (GKS) to treat diabetes mellitus.. |
| PC-63223 |
AMG-1694
|
AMG1694 is a potent, small molecule Glucokinase (GK)-GKRP (GK regulatory protein) disruptor, does not block the GK binding site directly. |
| PC-43024 |
AMG-3969
|
AMG-3969 is a potent, metabolically stable Glucokinase (GK)-GKRP (GK regulatory protein) disruptor with IC50 of 4 nM, does not block the GK binding site directly. |
| PC-61880 |
PF-04991532
|
PF-04991532 (PF4991532) is a potent, hepatoselective Glucokinase (GK) activator with EC50 of 90±45 nM. |
| PC-61877 |
AZD-1092
|
AZD-1092 (GKA-80) is a potent Glucokinase (GK) activator with EC50 of 30 nM. |
| PC-61876 |
PSN-GK1
|
PSN-GK1 is a potent, orally available Glucokinase (GK) activator with EC50 of 130 nM at 5 mM glucose (4.3-fold). |
| PC-61875 |
Piragliatin
|
Piragliatin (RO 4389620. |
| PC-61099 |
AM-9514
|
A potent gucokinase (GK) activator with EC50 of 0.29 uM. |
| PC-42677 |
Ro 28-1675
|
A potent, allosteric activator of Glucokinase (GK) with SC1.5 of 0.24 uM. |
