| Cat. No. |
Product Name |
Information |
| PC-47076 |
TC-D-F07
IRE1 inhibitor
|
TC-D-F07 is a novel prodrug of the covalent IRE-1 inhibitor D-F07, inhibits IRE-1/XBP-1s pathway in cancer cells. |
| PC-36004 |
KIRA8
IRE1α inhibitor
|
KIRA8 (AMG-18) is a highly potent, monoselective IRE1α kinase inhibitor with IC50 of 5.9 nM. |
| PC-36003 |
KIRA-7
IRE1α inhibitor
|
KIRA-7 is a small molecule inhibitor of IRE1α kinase/Rnase with IC50 of 0.11/0.22 uM, allosterically inhibits IRE1α RNase activity. |
| PC-62740 |
MKC9989
IRE1α inhibitor
|
MKC9989 is a specific small molecule inhibitor of IRE1α Rnase (Kd=0.84 uM) with potency against the splicing of XBP1 mRNA (EC50=0.33 uM).. |
| PC-62739 |
MKC8866
IRE1 inhibitor
|
MKC8866 (ORIN1001) is a spectific small molecule inhibitor of mammalian IRE1 RNase activity with IC50 of 0.29 uM. |
| PC-62196 |
IRE1α-IN-3
IRE1α inhibitor
|
IRE1α-IN-3 is a novel, potent IRE1α RNase inhibitor with EC50 of 0.82 uM. |
| PC-60595 |
GSK2850163
IRE1α inhibitor
|
GSK2850163 is a potent IRE1α-selective kinase inhibitor that inhibits both the kinase and RNase activities of IRE1α with IC50 of 20 nM and 200 nM, respectively. |
| PC-70079 |
CB5305630
IRE1 inhibitor
|
CB5305630 is a potent and noncompetitive IRE1 RNase inhibitor with IC50 of 60 nM in the FRET-derepression assay. |
| PC-70078 |
NSC95682
IRE1 inhibitor
|
NSC95682 is a potent and selective inhibitor of IRE1 endoribonuclease with IC50 of 0.41 uM. |
| PC-70077 |
3-Ethoxy-5,6-dibromosalicylaldehyde
IRE1 inhibitor
|
3-Ethoxy-5,6-dibromosalicylaldehyde is a potent and selective inhibitor of IRE1 endoribonuclease with IC50 of 0.12 uM. |
| PC-44755 |
STF-083010
IRE1 inhibitor
|
STF-083010 (STF083010) is a potent and selective IRE1 endoribonuclease inhibitor without affecting IRE1 kinase activity. |
| PC-45675 |
MKC3946
IRE1α inhibitor
|
MKC3946 (MKC-3946) is a small-molecule IRE1α endoribonuclease domain inhibitor, blocks XBP1 mRNA splicing and triggers growth inhibition in MM cells. |
