| Cat. No. |
Product Name |
Information |
| PC-25599 |
G-1749
IRE1 RNase activator
|
G-1749 is a potent, very kinase-selective and allosteric activator of IRE1 RNase activity with EC50 of 9 nM in RNase biochemical assay. |
| PC-25598 |
IAPD1
IRE1α inhibitor
|
IAPD1 is the ester prodrug of IA107 with improved cellular permeability, IA107 is a potent and selective inositol-requiring enzyme 1 alpha (IRE1α) inhibitor, IAPD1 potently inhibits ER stress-induced XBP1 splicing in A549 cells with IC50 of 180 nM. |
| PC-25597 |
IA107
IRE1α inhibitor
|
IA107 is a potent and selective inositol-requiring enzyme 1 alpha (IRE1α) inhibitor, inhibitsIRE1α and phosphorylated IRE1α RNase activity in FRET assay with IC50 of 16 nM and 9 nM, respectively. |
| PC-23415 |
IXA4
IRE1/XBP1s activator, SLC33A1 inhibitor
|
IXA4 is a specific activator of IRE1/XBP1s signalling activator, promotes IRE1-dependent XBP1 splicing, selective activates the IRE1/XBP1s signaling, also binds to SLC33A1 and inhibits its activity. |
| PC-23414 |
IXA6
IRE1/XBP1s activator
|
IXA6 is a specific activator of IRE1/XBP1s signalling activator, promotes IRE1-dependent XBP1 splicing, selective activates the IRE1/XBP1s signaling. |
| PC-22293 |
G-5758
IRE1α inhibitor
|
G-5758 (G5758) is a potent and selective, orally active IRE1α inhibitor with IC50 of 0.27 nM in HTRF IRE1α binding assays, inhibits IRE1α-Rnase with IC50 of 4.3 nM. |
| PC-49056 |
KIRA9
IRE1α inhibitor
|
KIRA9 is a potent inhibitor of IRE1α RNase activity with IC50 of 39 nM, blocks ER-localized mRNA decay and apoptosis. |
| PC-49055 |
PAIR1
IRE1α inhibitor
|
PAIR1 is a partial antagonist of IRE1α RNase (PAIR) that fully engage IRE1α's kinase domain (Ki=220 nM) but only partially inhibit its RNase activity. |
| PC-49054 |
PAIR2
IRE1α inhibitor
|
PAIR2 is a partial antagonist of IRE1α RNase (PAIR) that fully engage IRE1α's kinase domain (Ki=8.8 nM) but only partially inhibits its RNase activity. |
| PC-47079 |
KIRA6
IRE1α inhibitor
|
KIRA6 is a potent, ATP-competitive type II IRE1α kinase inhibitor, allosterically inhibits IRE1α RNase kinase activity with IC50 of 0.6 uM and prevents oligomerization. |
| PC-47078 |
B-I09
IRE1 inhibitor
|
B-I09 is a cell permeable IRE-1 RNase inhibitor with IC50 of 1.23 uM, inhibits IRE-1/XBP1 pathway, inhibits growth of human chronic lymphocytic leukemia (CLL) cells both in vitro and in vivo. |
| PC-47077 |
D-F07
IRE1 inhibitor
|
D-F07 is a novel fluorescent, covalent IRE-1 inhibitor, potently inhibits XBP-1s expression in MM cells. |
