| Cat. No. |
Product Name |
Information |
| PC-27678 |
CD155 inhibitor B7
CD155 inhibitor
|
CD155 inhibitor B7 is a blood-brain barrier-permeable small molecule CD155 (Poliovirus receptor, PVR) inhibitor, shows potent anti-proliferative activity GBM cell line LN229 with IC50 of 3.43 uM. |
| PC-27495 |
IL4I1-IN-1
IL4I1 inhibitor
|
IL4I1-IN-1 is a potent, selective interleukin 4-induced protein 1 (IL4I1) inhibitor with EC50 of 2 nM, inhibits IL4I1-mediated oxidative deamination of phenylalanine, reducing the production of phenylpyruvate, H2O2 and NH3. |
| PC-27380 |
GL-4512
LILRB4 inhibitor
|
GL-4512 a potent, small molecule direct modulator of leukocyte immunoglobulin-like receptor B4 (LILRB4, ILT3/CD85k) with SPR KD of 39.2 nM for binding to immobilized LILRB4 protein, inhibits LILRB4-SCG2 interaction with IC50 of 37 nM in TR-FRET assays, inhibits LILRB4-mediated immunosup pressive signaling pathways relevant to tumor immune evasion. |
| PC-27375 |
IB15C
ILT3 binder, ILT3-ApoE inhibitor
|
IB15C is a small molecule binder targeting the inhibitory immune receptor ILT3 (LILRB4, CD85k) with MST Kd of 0.92 uM, potently inhibits the ILT3-ApoE interaction with IC50 of 0.48 uM in ELISA-based competition assays. |
| PC-26971 |
ZY-MY-111
IL4I1 inhibitor
|
ZY-MY-111 is a selective, reversible, small-molecule inhibitor of interleukin-4-induced-1 (IL4I1) with IC50 of 1.86 uM, specifically targets the IL4I1-AHR axis and restores anti-tumor immunity. |
| PC-25905 |
LC427
LRBA-CTLA4 inhibitor, CTLA4 degrader
|
LC427 (LC-427) is a specific small molecule inhibitor of LRBA-CTLA4 interaction with IC50 of 0.18 uM, facilitates the lysosomal degradation of CTLA4, binds directly to PH-BEACH domain of LRBA with Kd of 19.6 uM. |
| PC-25880 |
BPU11
CD28 inhibitor
|
BPU11 is a specific small molecule CD28 inhibitor targeting CD28 costimulation with Kd of 6.5 uM, disrupts CD28-B7 interactions across biochemical and cellular systems. |
| PC-25821 |
LAGi-DEL
LAG-3 inhibitor
|
LAGi-DEL is a potent small molecule LAG-3 inhibitor, binds directly to LAG-3 with Kd value of 97 nM (SPR) and 271 nM (MST), disrupts the LAG-3/MHC-II interaction with EC50 of 138 nM. |
| PC-25773 |
CliMB-325
MHC‑I inducer
|
CliMB-325 is a small molecule modulator/ inducer of MHC‑I surface expression, induces MHC-I surface expression levels in CT26 cells with EC50 of 498 nM, also enhances T cell activation and exhibits lower toxicity. |
| PC-25371 |
LAG-3 inhibitor 11
LAG-3 inhibitor
|
LAG-3 inhibitor 11 is a potent, small molecule LAG-3 inhibitor, binds LAG-3 with MST KD of 0.41 uM, demonstrates disruption of the LAG-3/MHC II interaction in a cellular assay with EC50 of 0.31 uM. |
| PC-25299 |
19MS-5
CD28 inhibitor
|
19MS-5 is a specific small molecule CD28 inhibitor, exhibits direct CD28 binding (MST KD=12.48 uM) and potent inhibition of CD28-B7 interactions with IC50 of 5.2 uM in cellular reporter assays. |
| PC-25298 |
5MS-5
CD28 inhibitor
|
5MS-5 is a specific small molecule CD28 inhibitor, exhibits direct CD28 binding (MST KD=50.32 uM) and potent inhibition of CD28-B7 interactions with IC50 of 10.32 uM in cellular reporter assays. |
