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P62-mediated mitophagy inducer


P62-mediated mitophagy inducer (PMI) is a small molecule p62-mediated mitophagy inducer that activates mitophagy without recruiting Parkin or collapsing membrane potential and retains activity in cells devoid of a fully functional PINK1/Parkin pathway; induces doubling NQO1 activity at 1 uM, and upregulates Nrf2 and ARE-dependent antioxidant genes; increases the expression and signaling of the autophagic adaptor molecule P62/SQSTM1 and forces mitochondria into autophagy; disrupts the Nrf2-Keap1 interaction.


Urolithin A


A first-in-class natural compound that induces mitophagy both in vitro and in vivo following oral consumption; prevents the accumulation of dysfunctional mitochondria with age and extends lifespan in C. elegans, improves exercise capacity in mouse models of age-related decline of muscle function.


Mtphagy Dye

2137473-96-0 Mtphagy Dye is a small-molecule fluorescent probe for visualizing mitophagy; has suitable fluorescent properties for detecting mitochondrial acidification during mitophagy in the long-wavelength region that does not damage mitochondria.

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