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Cat. No. Product Name Information
PC-45725

C-DIM12

NURR1 (NR4A2) agonist

C-DIM12 is a NR4A2 (Nurr1) activator that inhibits NF-κB-dependent gene expression in glial cells by stabilizing nuclear corepressor CoREST and NCOR2.
PC-21259

Nurr1 agonist 5o

NURR1 agonist

Nurr1 agonist 5o is a small molecule agonist of the transcription factor Nurr1 with Kd of 0.5 uM and EC50 of 3 uM.
PC-21004

4A7C-301

Nurr1 agonist

4A7C-301 is a potent, selective, brain-penetrant agonist of nuclear receptor Nurr1 with EC50 of 6.53 uM, binds to Nurr1 ligand binding domain (LBD) with IC50 of 50 nM.
PC-20774

XCT0135908

Nurr1-RXR agonist

XCT0135908 (BRF001) is a highly selective activator of Nurr1-RXR heterodimers, stimulates dopamine (DA) neuron survival.
PC-20773

BRF110

Nurr1-RXRα agonist

BRF110 is a potent, selective, brain penetrant and vivo active agonist of Nurr1-RXRα heterodimers with EC50 of 900 nM.
PC-20772

SA00025

NURR1 agonist

SA00025 is a potent, specific and brain penetrant agonist of Nurr1 (NR4A2) with EC50 of 2.5 nM in HEK293 cells transfected with full length human Nurr1.
PC-20771

Amodiaquine

NURR1 agonist

Amodiaquine (Amodiaquin, AQ) is an antimalarial agent and nuclear receptor Nurr1 (NR4A2) agonist, specifically binds to Nurr1-LBD (ligand binding domain) with EC50 of 20 uM.
PC-20770

Nurr1 inverse agonist 31

Nurr1 modulator

Nurr1 inverse agonist 31 is a small molecule inverse agonist of Nurr1 (NR4A2) with IC50 of 2.3 uM, mimicks the effect of Nurr1 silencing on interleukin-6 release from LPS-stimulated human astrocytes.
PC-20768

Nurr1 agonist 29

NURR1 (NR4A2) agonist

Nurr1 agonist 29 is a potent, selective nuclear receptor related 1 (Nurr1, NR4A2) agonist with EC50 of 0.11 uM.

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