| Cat. No. |
Product Name |
CAS No. |
Information |
| PC-49639 |
HQL-79
|
162641-16-9 |
HQL-79 (HQL79) is an orally selective inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS), inhibits human H-PGDS competitively against the substrate PGH2 and non-competitively against GSH with Ki of 5 and 3 uM, respectively. |
| PC-49638 |
GSK2894631A
|
2101626-26-8 |
GSK2894631A (GSK-2894631A) is a potent and specific inhibitor of hematopoietic PGD synthase (HPGDS) with IC50 of 9.9 nM. |
| PC-49637 |
H-PGDS inhibitor 1y
|
2255311-93-2 |
H-PGDS inhibitor 1y is a potent peripherally restricted H-PGDS inhibitor with IC50 of 9.4 nM, compound 1y is efficacious in four in vivo inflammatory models and exhibits no CNS toxicity. |
| PC-49636 |
H-PGDS inhibitor 8
|
1033836-12-2 |
H-PGDS inhibitor 8 is a potent, selective and orally active hematopoietic prostaglandin D synthase (HPGDS) inhibitor with enzyme IC50 of 0.6 nM, and cell IC50 of 32 nM. |
| PC-49465 |
GS-248
|
1360622-01-0 |
Vipoglanstat (GS-248, BI 1029539) is a potent, selective and orally active membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitor with IC50 of 0.4 nM in human whole-blood assay (hWBA). |
| PC-49237 |
MPO-0144
|
2766397-73-1 |
MPO-0144 (MPO 0144) is a potent, selective mPGES-1 inhibitor (PGE2 IC50=41.77 nM, mPGES-1 IC50=1.16 nM), exhibits potent neuroprotection (ED50=3.0 nM) against 6-OHDA-induced in PC12 cells without significant neurotoxicity (IC50>10 uM). |
| PC-38689 |
LY3023703
|
1415089-24-5 |
LY3023703 is a potent, highly selective microsomal prostaglandin E synthase 1 (mPGES1) inhibitor, dose-dependently inhibits PGE2 production in human whole blood ex vivo. |
