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Cat. No. Product Name CAS No. Information


162641-16-9 HQL-79 (HQL79) is an orally selective inhibitor of human hematopoietic prostaglandin D synthase (H-PGDS), inhibits human H-PGDS competitively against the substrate PGH2 and non-competitively against GSH with Ki of 5 and 3 uM, respectively.


2101626-26-8 GSK2894631A (GSK-2894631A) is a potent and specific inhibitor of hematopoietic PGD synthase (HPGDS) with IC50 of 9.9 nM.

H-PGDS inhibitor 1y

2255311-93-2 H-PGDS inhibitor 1y is a potent peripherally restricted H-PGDS inhibitor with IC50 of 9.4 nM, compound 1y is efficacious in four in vivo inflammatory models and exhibits no CNS toxicity.

H-PGDS inhibitor 8

1033836-12-2 H-PGDS inhibitor 8 is a potent, selective and orally active hematopoietic prostaglandin D synthase (HPGDS) inhibitor with enzyme IC50 of 0.6 nM, and cell IC50 of 32 nM.


1360622-01-0 Vipoglanstat (GS-248, BI 1029539) is a potent, selective and orally active membrane-associated prostaglandin E synthase-1 (mPGES-1) inhibitor with IC50 of 0.4 nM in human whole-blood assay (hWBA).


2766397-73-1 MPO-0144 (MPO 0144) is a potent, selective mPGES-1 inhibitor (PGE2 IC50=41.77 nM, mPGES-1 IC50=1.16 nM), exhibits potent neuroprotection (ED50=3.0 nM) against 6-OHDA-induced in PC12 cells without significant neurotoxicity (IC50>10 uM).


1415089-24-5 LY3023703 is a potent, highly selective microsomal prostaglandin E synthase 1 (mPGES1) inhibitor, dose-dependently inhibits PGE2 production in human whole blood ex vivo.

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