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537-42-8 Pterostilbene is a natural phenolic compound, dimethylated derivative of resveratrol that has potent antitumor activity against several human cancer types; induces strong and sustained activation of ERK1/2, with concomitant cyclin D1 suppression and p21 up-regulation, and inhibits the phosphorylation of AKT and mTOR in MDA-MB-468 cells; synergizes the antineoplastic effects of megestrol acetate in endometrial cancer; also targets MTA1/HDAC signaling with deacetylation of tumor suppressors p53 and PTEN in prostate cancer cells.

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