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Request The Product List ofPolo-like Kinase (PLK) Polo-like Kinase (PLK)

Cat. No. Product Name Information
PC-73207

ON1231320

PLK2 inhibitor

ON1231320 is a highly specific, ATP-mimetic polo-like kinase 2 (PLK2) inhibitor with IC50 of 0.31 uM.
PC-63238

CFI-400945 fumarate

PLK4 inhibitor

CFI-400945 (Ocifisertib) fumarate is a potent, highly selective, orally available PLK4 inhibitor with Ki of 0.26 nM and IC50 of 2.8 nM, does not significantly inhibits PLK1/2/3 at 50 uM.
PC-42963

CFI-400945

PLK4 inhibitor

CFI-400945 is a potent, highly selective PLK4 inhibitor with Ki of 0.26 nM and IC50 of 2.8 nM, does not significantly inhibits PLK1/2/3 at 50 uM.
PC-42899

Volasertib

PLK inhibitor

Volasertib (BI 6727) is a potent, selective Polo-like kinase (PLK) inhibitor with IC50 of 0.87, 5 and 56 nM for PLK1, 2 and 3, respectively.
PC-42860

HMN-214

PLK1 inhibitor

HMN-214 (IVX 214, TV-7101) is a prodrug of HMN-176 for oral administration, HMN-176 is a stilbene derivative that interferes with the subcellular spatial location of PLK1, does not inhibit PLK directly.
PC-42852

Rigosertib

PLK1 inhibitor

Rigosertib (ON 01910) is a potent, non-ATP-competitive PLK1 inhibitor (IC50=9-10 nM), selectively induces mitotic G2/M arrest and apoptosis in cancer cells.
PC-42851

Rigosertib sodium

PLK1 inhibitor

Rigosertib sodium (ON 01910.Na) is a potent, non-ATP-competitive PLK1 inhibitor (IC50=9-10 nM), selectively induces mitotic G2/M arrest and apoptosis in cancer cells.
PC-63063

T-521

PLK1 inhibitor

T-521 is a novel PLK1 PBD (Polo-box domain) inhibitor that specifically inhibits the PBD of PLK1 (IC50=1.22 uM), but not those of Plk2-3.
PC-62790

PLK1-IN-14f

PLK1 inhibitor

PLK1-IN-14f is a potent PLK1 inhibitor, exhibits potent activity against a panel cancer cell lines with GI50 values ranging from 0.30 to 0.60 uM.
PC-62393

Poloxin

PLK1 inhibitor

Poloxin is the first reported PLK1 PBD inhibitor with IC50 of 6.4 uM, shows less potent inhibition for Plk2 PBD and Plk3 PBD.
PC-62159

Cyclapolin 1

PLK1 inhibitor

Cyclapolin 1 is a potent and selective PLK1 inhibitor that promotes loss of centrosome integrity and microtubule nucleating ability apparently through increased accessibility of protein phosphatases.
PC-62158

Cyclapolin 9

PLK1 inhibitor

Cyclapolin 9 is a potent, selective, and ATP-competitive polo-like kinase PLK1 inhibitor with IC50 of 500 nM.

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