| Cat. No. |
Product Name |
Information |
| PC-22122 |
NST-628
RAF-MEK molecular glue
|
NST-628 is a potent, brain-penetrant, pan-RAF-MEK molecular glue, prevents phosphorylation and activation of MEK by RAF, leading to deep durable inhibition of MEK kinase activity and downstream ERK signaling. |
| PC-21219 |
Exarafenib
pan-RAF inhibitor
|
Exarafenib (KIN-2787) is a highly potent and selective pan-RAF inhibitor with IC50 of 2.4/3.5/1.4 nM for ARAF/BRAF/CRAF, respectively. |
| PC-72612 |
PF-07284890
BRAF V600 mutants inhibitor
|
PF-07284890 (ARRY-461) is an orally bioavailable, brain penetrant, potent, small molecule BRAF V600 mutants inhibitor, inhibits BRAF and CRAF with IC50 of 5.8 and 4.1 nM, respectively. |
| PC-72469 |
GNE-9815
pan-RAF inhibitor
|
GNE-9815 (GNE9815) is a potent, selective, oral Type II pan-RAF inhibitor with Ki of 0.062 and 0.19 nM for CRAF and BRAF, respectively. |
| PC-72243 |
BRAF inhibitor Compound Ia
BRAF inhibitor
|
BRAF inhibitor Compound Ia is a potent, selective, brain penetrant BRAF inhibitor with binding Kd of 0.6, 1.2, and 1.7 nM for BRAF WT, BRAF V600E, and c-RAF, presenting paradox breaker properties. |
| PC-72242 |
PLX8394
BRAF inhibitor
|
PLX8394 (Plixorafenib, PLX-8394) is a next-generation, orally available, small-molecule BRAF inhibitor with IC50 values of 3.8 nM, 14 nM and 23 nM for BRAF (V600E), WT BRAF and CRAF, respectively. |
| PC-35635 |
LXH254
|
LXH254 (Naporafenib, LXH 254) is a highly potent, selective B/C RAF inhibitor with Kd of 1.3/3.6 nM respectively, shows less activity against ARAF. |
| PC-35100 |
RRD-251
Rb/Raf-1 inhibitor
|
RRD-251 is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM) but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/HDAC binding. |
| PC-63557 |
BI 882370
RAF inhibitor
|
BI 882370 is a highly potent, selective, orally active pan-RAF inhibitor with IC50 of 0.4, 0.8 and 0.6 nM for BRAF V600E, BRAF WT and CRAF, respectively. |
| PC-43507 |
ZM 336372
c-Raf inhibitor
|
ZM 336372 is a potent, specific inhibitor of Raf isoforms in vitro (c-Raf IC50=70 nM), paradoxically induces >100-fold activation of c-Raf (Raf-1 activator), but without triggering any activation of MKK1 or p42 MAPK/ERK2. |
| PC-43107 |
LY3009120
RAF inhibitor
|
LY3009120 (DP-4978) is a potent pan-RAF and RAF dimer inhibitor with IC50 of 5.8, 9.1 and 15 nM for BRAF V600E, BRAF WT and CRAF WT, respectively. |
| PC-42871 |
Vemurafenib
B-Raf V600E inhibitor
|
Vemurafenib (PLX-4032, RG7204, RO5185426) is a potent, selective B-RAF V600E inhibitor with IC50 of 30 nM, displays similar potency for c-RAF-1 (IC50=48 nM), and has selectivity against many other kinases, including wild type B-RAF (IC50=100nM). |
