Cat. No. |
Product Name |
Information |
PC-49770 |
Encorafenib
BRAF inhibitor
|
Encorafenib (NVP-LGX818, LGX818) a potent, selective BRAF inhibitor with IC50 of 0.35, 0.47, and 0.3 nM against BRAF V600E, wild-type BRAF and CRAF in vitro cell-free assays, respectively. |
PC-73450 |
AZD628
pan-RAF inhibitor
|
AZ628 (AZD-628) is a potent, selective, pan-RAF kinase inhibitor with IC50 of 105, 29 and 34 nM against for wild-type CRAF, BRAF V600E, and c-Raf-1, respectively. |
PC-73449 |
Tovorafenib
pan-RAF inhibitor
|
Tovorafenib (MLN2480, TAK-580) is potent, selective, brain-penetrant RAF dimer antagonist, inhibits MAP kinase pathway signaling in BRAF-mutant melanoma models. |
PC-72530 |
TAK-632
pan-RAF inhibitor
|
TAK-632 (TAK632) is a potent, selective pan-RAF inhibitor with IC50 of 1.4, 2.4 and 8.3 nM for CRAF, BRAF V600E and BRAF WT, respectively. |
PC-35347 |
Balamapimod
|
Balamapimod (MKI-833) is an orally active, reversible Ras/Raf/MEK inhibitor developed for antineoplastic potential.. |
PC-35099 |
RRD-251 hydrochloride
|
RRD-251 hydrochloride is a small molecule disruptor of Rb/Raf-1 interaction, potently and selectively disrupts the Rb/Raf-1 (IC50=77 nM) but not Rb/E2F, Rb/prohibitin, Rb/cyclin E, and Rb/HDAC binding. |
PC-63581 |
AZ304
|
AZ304 is a novel potent, dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF and wild type CRAF with IC50 of 79 nM, 38 nM and 68 nM, respectively. |
PC-63267 |
CCT241161
|
CCT241161 is a potent pan-RAF inhibitor with IC50 of 30, 15 and 6 nM for BRAF, V600E-BRAF and C-RAF, also potently inhibits SRC and LCK (IC50=10 and 3 nM, respectively).. |
PC-43255 |
CCT196969
|
CCT196969 is a potent, orally bioavailable pan-RAF inhibitor with IC50 of 100, 40 and 12 nM for B-Raf, B-Raf V600E and C-Raf, respectively. |
PC-43208 |
L-779450
|
L-779450 is a potent, ATP-competitive Raf kinase inhibitor with IC50 of 10 nM, displays >7, >30 and >70-fold selectivity over p38α, GSK3β and Lck respectively. |
PC-62702 |
EBI-907
|
EBI-907 is a highly potent, selective, orally active B-Raf V600E inhibitor with enzyme IC50 of 7 nM, A375 cell growth IC50 of 13 nM. |
PC-61974 |
REDX-05358
|
REDX-05358 is a novel potent, highly selective, orally bioavailable pan RAF inhibitor with IC50 of 0.1, 0.68, 0.171, and 0.076 nM for ARAF, BRAF, BRAF (V600E), and CRAF, respectively. |