| Cat. No. |
Product Name |
Information |
| PC-22869 |
ETC-451
Wntless inhibitor
|
ETC-451 (ETC-2188451) is a specific small molecule inhibitor of the Wnt transporter Wntless (WLS/Evi) with IC50 of 7.7 uM in Wnt/β-catenin reporter assays in STF3A cells, blocks the interaction of Wnt with Wntless. |
| PC-21946 |
CGK012
Wnt/β-catenin inhibitor
|
CGK012 is a small-molecule inhibitor of the Wnt/β-catenin signaling pathway, exerts antiseptic effects against HMGB1 septic responses. |
| PC-20893 |
WNTinib
Wnt/β-catenin inhibitor
|
WNTinib is a multi-kinase inhibitor with specificity against β-catenin (CTNNB1) mutant hepatocellular carcinoma, harnesses the KIT/MAPK/EZH2 pathway, shows durable and selective transcriptional repression of mutant β-catenin/Wnt targets through nuclear translocation of the EZH2 transcriptional repressor. |
| PC-49509 |
YW2065
Wnt inhibitor, AMPK activator
|
YW2065 is is a small molecule inhibitor of Wnt signaling by stabilizing Axin-1, also activates the tumor suppressor AMPK, demonstratesexcellent anti-CRC effects in vitro and in vivo. |
| PC-49508 |
SEN461
Wnt inhibitor
|
SEN461 (SEN 461) is a potent small molecule inhibitor of canonical WNT signaling, inhibits WNT reporter activity in the DBTRG cell line with IC50 of 1.3 uM, acts through AXIN stabilization. |
| PC-38719 |
C644-0303
Wnt/β-catenin inhibitor
|
C644-0303 is a novel Wnt/β-catenin signaling inhibitor (IC50=4.2 uM) with antitumor efficacy, inhibits both constitutive and ligand activated Wnt signals and its downstream gene expression. |
| PC-38354 |
Dalosirvat
Wnt modulator
|
Dalosirvat (SM04554) is a small-molecule Wnt pathway modulator, activates Wnt with IC50 of 28-29 nM, with potential topical treatment for androgenetic alopecia. |
| PC-35711 |
DK419
Wnt/β-catenin inhibitor
|
DK419 (DK-419) a potent, orally acitve inhibitor of Wnt/β-catenin signaling with IC50 of 0.19 uM in Wnt3A-stimulated TOPFlash assays. |
| PC-35498 |
PAWI-2
Wnt inhibitor
|
PAWI-2 is a small molecule inhibitor targets both Wnt signaling and ATM/p53, potently inhibits Wnt transcription (IC50=11 nM) and p53 transcription (EC50=1.9 nM). |
| PC-35020 |
Box5
Wnt5a inhibitor
|
Box5 is a Wnt5a-derived N-butyloxycarbonyl hexapeptide (t-Boc-Met-Asp-Gly-Cys-Glu-Leu), acts as an Wnt5a antagonist. |
| PC-42972 |
Cardiogenol C hydrochloride
Wnt activator
|
Cardiogenol C is a small cell-permeable molecule that selectively and efficiently induce mouse embryonic stem cells (ESCs) to differentiate into cardiomyocytes with EC50 of 0.1 uM, activates Wnt signaling pathway. |
| PC-62447 |
Cardionogen 1
Wnt inhibitor
|
Cardionogen 1 (CDNG1) is a small molecule that promotes cardiomyocyte generation by modulating Wnt signaling. |
