| Cat. No. |
Product Name |
Information |
| PC-21253 |
AF-2112
TEAD inhibitor
|
AF-2112 is a small molecule inhibitor of TEAD, reduces the expression of CTGF, Cyr61, Axl and NF2, inhibits migration of human MDA-MB-231 breast cancer cells. |
| PC-21252 |
TEAD inhibitor LM41
TEAD inhibitor
|
TEAD inhibitor LM41 is a small molecule inhibitor of TEAD, reduces the expression of CTGF, Cyr61, Axl and NF2, inhibits migration of human MDA-MB-231 breast cancer cells. |
| PC-20409 |
TEAD activator Q2
TEAD activator
|
TEAD activator Q2 (Quinolinol Q2) is a small molecule activator of TEAD with EC50 of 2.6 uM in TEAD dual-luciferase reporter (DLR) assays, inhibits TEAD-palmitate interaction with IC50 of 1.7 uM. |
| PC-20408 |
NSC682769
YAP-TEAD inhibitor
|
NSC682769 is a specific YAP-TEAD signaling inhibitor, blocks the association of the YAP and TEAD interaction interface, directly binds to YAP with Kd of 738 nM. |
| PC-20405 |
TEAD inhibitor 6
TEAD inhibitor
|
TEAD inhibitor 6 is a highly potent TEAD inhibitor, disrupts the YAP-TEAD interaction with IC50 of 2.7 nM, binds the main interaction site of YAP at the surface of TEAD. |
| PC-49697 |
TED-642
TEAD-YAP1 inhibitor
|
TED-642 (TED642) is a potent, covalent, pan-TEAD-YAP1 antagonist, inhibits TEAD1/2/4 binding to YAP with IC50 of 0.9-1.2 uM. |
| PC-49541 |
MGH-CP1
TEAD inhibitor
|
MGH-CP1 is a specific small molecule TEAD palmitoylation inhibitor, exhibits dose-dependent and potent inhibition of TEAD2/4 auto-palmitoylation in vitro with IC50 of 710 nM and 672 nM, respectively. |
| PC-49416 |
YAP inhibitor JM7
YAP-TEAD inhibitor
|
JM7 is a small-molecule that inhibits TEAD palmitoylation and stability, affects YAP-TEAD interaction and inhibits YAP transcriptional activity and impairs proliferation, colony formation and migration of breast and ovarian cancer cells. |
| PC-49408 |
MYF-03-69
YAP-TEAD inhibitor
|
MYF-03-69 is a selective, covalent, irreversible TEAD inhibitor, binds with TEAD palmitate pocket, disrupts YAP-TEAD association, suppresses TEAD transcriptional activity (IC50=45 nM) and inhibits cell growth of defective Hippo signaling. |
| PC-49185 |
TAT-PDHPS1
YAP inhibitor
|
TAT-PDHPS1 is an endogenous stable peptide that inhibits the proliferation of ovarian cancer cells in vitro, regulates ovarian cancer development through targeting YAP1 signaling, binds to and interacts with protein phosphatase 2 phosphatase activator (PTPA). |
| PC-49184 |
PDHPS1
YAP inhibitor
|
PDHPS1 is an endogenous stable peptide which is derived from the C-terminal (2090-2110) of NUMA1, inhibits the proliferation of ovarian cancer cells in vitro, regulates ovarian cancer development through targeting YAP1 signaling, binds to and interacts with protein phosphatase 2 phosphatase activator (PTPA). |
| PC-73283 |
DC-TEAD3in03
TEAD3 inhibitor
|
DC-TEAD3in03 is a potent, selective, covalent TEAD3 inhibitor with IC50 of 0.16 uM, 100-fold selectivity over other TEAD isoforms (IC50>20 uM) in ABPP assays. |
