| Cat. No. |
Product Name |
Information |
| PC-72427 |
LM98
YAP-TEAD inhibitor
|
LM98 (TEAD inhibitor LM98) is a flufenamic acid analogue, shows strong affinity to TEAD, inhibits its autopalmitoylation and reduces the YAP-TEAD transcriptional activity. |
| PC-72171 |
K-975
TEAD inhibitor
|
K-975 (K975, YAP1-TEAD inhibitor K975) is a potent, specific inhibitor of YAP1/TAZ-TEAD signaling, inhibits YAP1/TAZ-TEAD protein-protein interaction, a pan-TEAD inhibitor binds to Cys359 of TEAD1-YBD. |
| PC-38304 |
Annexin A2 inhibitor PY-60
ANXA2 inhibitor, YAP activator
|
Annexin A2 inhibitor PY-60 (PY-60) is a novel small molecule activator of YAP transcriptional activity (EC50=1.5 uM) via targeting annexin A2 (ANXA2). |
| PC-38143 |
TEAD inhibitor Compound 2
TEAD antagonist
|
TEAD inhibitor Compound 2 (TEAD-IN-2) is a small molecule TEAD antagonist (TEAD2 IC50=603 nM FP assays, SPR Kd=229 nM) that binds the TEAD lipid pocket and disrupts TEAD S-palmitoylation. |
| PC-36118 |
Verteporfin
YAP inhibitor
|
Verteporfin (CL 318952, BPD-MA) is a benzoporphyrin derivative that inhibits Yap via disruption of YAP-TEAD interactions, Verteporfin is a clinically used photosensitizer. |
| PC-36034 |
IBS003031
YAP1 activator
|
IBS003031 (IBS-003031) is a novel chemical Yes-associated protein 1 (YAP1) activator, up-regulates H2B-mCherry expression at 1 and 3 uM in mCherry signal based reporter assays. |
| PC-35898 |
TED-347
YAP-TEAD4 inhibitor
|
TED-347 (TED347) is an irreversible inhibitor of TEAD4-Yap1 protein-protein interaction (EC50=5.9 uM in FP asssays) via covalent modification of conserved cysteine (Cys367, Ki=1.3 uM), inhibits its binding to Yap1, blocked its transcriptional activity. |
| PC-35820 |
TT-10
YAP activator
|
TT-10 (YAP-TEAD activator TT-10, TAZ-K) is a small molecule activator that activates pro-proliferative YES-associated protein (YAP) and transcriptional enhancer factor domain (TEAD) activities in cardiomyocytes. |
| PC-60375 |
YAP1 inhibitor CA3
YAP1 inhibitor, Ferroptosis inducer
|
YAP1 inhibitor CA3 (CA3, CIL56) is a small molecule that has remarkable inhibitory activity on YAP1/TEAD transcriptional activity |
| PC-25992 |
MSC-4070
TEAD inhibitor
|
MSC-4070 is a selective, brain-penetrant TEAD1/2/4 inhibitor with IC50 of 14 nM in TEAD reporter assays in SK-HEP-1 cells, with selectivity for TEAD1, 2, 4 over TEAD3, has IC50 of 30 nM in NCI-H226 viability assays. |
| PC-24744 |
Cyclovirobuxine D
YAP inhibitor
|
Cyclovirobuxine D (CVB-D) is a naturally alkaloid, induces autophagy and attenuates the phosphorylation of Akt and mTOR, exerts its anti-cancer effects by directly binding to YAP, inhibits the nuclear translocation of YAP/TAZ and suppresses the transcription of downstream oncogenic target genes. |
| PC-24521 |
TJ-M11
YAP/TAZ inhibitor
|
TJ-M11 is a synthesized peptide inhibitor of YAP/TAZ transactivation domain (TAD), specifically blocks YAP transactivation (IC50=5.96 uM, NCI-H1299 cells) by disrupting its TAD interactions with the cofactors MED15 and TAF4. |
