| Cat. No. |
Product Name |
Information |
| PC-42092 |
CZ-415
mTOR inhibitor
|
CZ-415 (CZ415) potent, highly selective, ATP-competitive and orally bioavailable mTOR inhibitor with pKd of 8.2. |
| PC-42577 |
OSI-027
mTOR inhibitor
|
OSI-027 is a potent and selective inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively. |
| PC-42038 |
PQR-620
mTOR inhibitor
|
PQR-620 (PQR620) is a potent and selective, brain penetrant inhibitor of mTORC1/2, displays >1000-fold selectivity towards mTOR over PI3Kα in enzymatic binding assays. |
| PC-42464 |
Rapamycin
mTOR inhibitor
|
Rapamycin (Sirolimus) is a macrolide compound that has potent immunosuppressive and antiproliferative properties by inhibiting mTOR (IC50=0.1 nM), induces autophagy. |
| PC-21000 |
AZD2014
mTOR inhibitor
|
Vistusertib (AZD2014) is a potent and selective dual mTORC1 and mTORC2 inhibitor, inhibits both mTORC1 and mTORC2 in vitro (pS6 (S235/236), IC50=0.2 μM, pAKT (S473) IC50=0.08 μM). |
| PC-49618 |
RMC-6272
mTORC1 inhibitor
|
RMC-6272 (RMC6272) is a potent, selective bi-steric inhibitor of mTORC1 with cellular IC50 of 0.44 nM for p4EBP1 inhibition, 27-fold selectivity over mTORC2. |
| PC-49617 |
RMC-5552
mTORC1 inhibitor
|
RMC-5552 (RMC5552) is a potent, selective bi-steric inhibitor of mTORC1 with cellular IC50 of 0.48 nM for p4EBP1 inhibition, 40-fold selectivity over mTORC2. |
| PC-49337 |
NV-5297
mTORC1 activator
|
NV-5297 (NV5297) is a novel small molecule mTORC1 pathway activator, modulates the Sestrin2-Gator2 interaction and activates the mTORC1 pathway in vitro and in vivo. |
| PC-35518 |
ICSN3250 hydrochloride
|
ICSN3250 (ICSN-3250) hydrochloride is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors. |
| PC-35070 |
Seco Rapamycin
|
Seco-rapamycin is the first in vivo open-ring metabolite of rapamycin that does not affect mTOR.. |
| PC-62364 |
CID3528206
|
CID3528206 is a potent, small molecule yeast TORC1 inhibitor that inhibits TORC1 activity both in vitro and in vivo with IC50 of 150 nM and 3.9 uM, respectively. |
| PC-62011 |
CIDD 0067106
|
CIDD 0067106 is a novel natural product-based diaryloxazole that potent and selective antiproliferative activities against androgen receptor-positive breast cancer cells (MDA-MB-453 cell GI50=0.8 uM). |
