p97/VCP compound (inhibitors, antagonists, modulators)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-25308	Eeyarestatin I VCP inhibitor, ERAD inhibitor, Sec61 inhibitor	Eeyarestatin I (Eeyarestatin 1, ESI, ES1) is a potent endoplasmic reticulum-associated protein degradation (ERAD) inhibitor, targets the p97-associated deubiquitinating process (PAD) and inhibits atx3-dependent deubiquitination, inhibits Sec61 translocon.
PC-24319	DBeQ p97/VCP inhibitor, VPS4 inhibitor	DBeQ is a selective, potent, reversible, and ATP-competitive AAA ATPase p97/VCP inhibitor with IC50 of 1.5 μM and 1.6 μM for p97(wt) and p97(C522A) respectively, also inhibits VPS4 with IC50 of 11.5 uM.
PC-22873	Thonzonium bromide p97-Npl4 inhibitor	Thonzonium bromide is an antibacterial agent, inhibits RANKL-induced osteoclast formation and bone resorption in vitro and prevents LPS-induced bone loss in vivo, also is a ATPase p97-Npl4 interaction, boosts antitumor immunity without affecting peripheral Treg cell homeostasis.
PC-20932	UPCDC-30766 p97/VCP inhibitor	UPCDC-30766 (UPCDC 30766) is a potent, allosteric inhibitor of AAA+ ATPase p97 (valosin-containing protein, VCP) with biochemical IC50 of 12 nM, EC50 of 226 nM in cellular UbG76V-GFP accumulation assays.

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