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Chemical Structure : ABCA1 inducer Cpd G
CAS No.: 1269826-44-9
Catalog No.: PC-72587Not For Human Use, Lab Use Only.
ABCA1 inducer Cpd G (Cpd G) is a small molecule inducer of ABCA1-mediated cholesterol efflux that targets Oxysterol Binding Protein Like 7 (OSBPL7).
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|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $428 | In stock | |
| 25 mg | $728 | In stock | |
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ABCA1 inducer Cpd G (Cpd G) is a small molecule inducer of ABCA1-mediated cholesterol efflux that targets Oxysterol Binding Protein Like 7 (OSBPL7).
Cpd G displays little to no binding affinity to the CB1R (Ki>1 uM).
Cpd G increases plasma membrane ABCA1 in cultured human podocytes, and significantly increases ABCA1-dependent cholesterol efflux at 10 uM.
Cpd G significantly increased apoAI-mediated cholesterol efflux at 10 uM.
Cpd G (100 mg/Kg) protects from kidney injury in a mouse model of adriamycin-induced nephropathy.
Cpd G protects from renal injury in the mouse model of Alport syndrome.
Cpd G reduced accumulation of cholesterol esters in renal cortex in both disease models.
| M.Wt | 463.278 | |
| Formula | C20H19Cl2F3N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
5-(3,4-dichlorophenyl)-N-((1R,2R)-2-hydroxycyclohexyl)-6-(2,2,2-trifluoroethoxy)nicotinamide |
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1. Matthew B Wright, et al. Nat Commun. 2021 Aug 2;12(1):4662.
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