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Chemical Structure : AEE-788
CAS No.: 497839-62-0
Catalog No.: PC-42158Not For Human Use, Lab Use Only.
AEE-788 (AEE788) is a potent, orally bioavailable dual EGFR/VEGFR receptor tyrosine kinase inhibitor with IC50 of 2, 6, 77 and 59 nM for EGFR, ErbB2, KDR and Flt-1, respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 50 mg | $118 | In stock | |
| 100 mg | $188 | In stock | |
| 200 mg | Get quote | ||
| 1 g | Get quote |
Bulk size, bulk discount!
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AEE-788 (AEE788) is a potent, orally bioavailable dual EGFR/VEGFR receptor tyrosine kinase inhibitor with IC50 of 2, 6, 77 and 59 nM for EGFR, ErbB2, KDR and Flt-1, respectively.
AEE-788 (AEE788) inhibits growth factor-induced EGFR and ErbB2 phosphorylation in cells with IC50 of 11 and 220 nM, respectively.
AEE-788 (AEE788) demonstrates antiproliferative activity against a range of EGFR and ErbB2-overexpressing cell lines.
AEE-788 (AEE788) shows antitumor and antiangiogenic activity in vivo.
| M.Wt | 440.5832 | |
| Formula | C27H32N6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: 10 mM |
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| Chemical Name/SMILES |
7H-Pyrrolo[2,3-d]pyrimidin-4-amine, 6-[4-[(4-ethyl-1-piperazinyl)methyl]phenyl]-N-[(1R)-1-phenylethyl]- |
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1. Traxler P, et al. Cancer Res. 2004 Jul 15;64(14):4931-41.
2. Goudar RK, et al. Mol Cancer Ther. 2005 Jan;4(1):101-12.
3. Park YW, et al. Clin Cancer Res. 2005 Mar 1;11(5):1963-73.
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