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AVN-322 free base

Chemical Structure : AVN-322 free base

CAS No.: 1194574-33-8

AVN-322 free base (AVN 323 free base)

Catalog No.: PC-61503Not For Human Use, Lab Use Only.

A highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A highly selective, potent, BBB penetrant and orally bioavailable 5-HT6R antagonist for the treatment of neurological disorders such as AD and schizophrenia; significantly restores both scopolamine- and MK-801-induced cognitive dysfunction and demonstrates antipsychotic potential.

Alzheimer Disease

Phase 2 Clinical

Physicochemical Properties

M.Wt 357.432
Formula C17H19N5O2S
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

N,7-dimethyl-3-(phenylsulfonyl)-6,7,8,9-tetrahydropyrazolo[1,5-a]pyrido[3,4-e]pyrimidin-2-amine hydrochloride

References

1. Ivachtchenko AV, et al. Curr Alzheimer Res. 2017;14(3):268-294.

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