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Chemical Structure : AY-9944
Catalog No.: PC-62176Not For Human Use, Lab Use Only.
AY-9944 is a cholesterol biosynthesis inhibitor that targets the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM), attenuates of Smoothened-dependent and -independent Hh signaling.
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AY-9944 is a cholesterol biosynthesis inhibitor that targets the 7-dehydro cholesterol Δ7-reductase (DHCR7) enzyme (IC50=13 nM), attenuates of Smoothened-dependent and -independent Hh signaling; has been used to recapitulate phenotypes of Smith-Lemli-Opitz syndrome in animal model.
| M.Wt | 464.3 | |
| Formula | C22H28Cl2N2 • 2HCl | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Horlick L. J Lipid Res. 1966 Jan;7(1):116-21.
2. Lauth M, et al. Mol Pharmacol. 2010 Sep;78(3):486-96.
3. Xu L, et al. J Lipid Res. 2011 Oct;52(10):1810-20.
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