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Chemical Structure : AZ-876
CAS No.: 898800-26-5
Catalog No.: PC-45444Not For Human Use, Lab Use Only.
AZ-876 (AZ876) is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $328 | In stock | |
| 100 mg | Get quote |
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AZ-876 (AZ876) is a potent, highly selective LXR agonist with Ki/EC50 of 7/6 nM and 11/73 nM for hLXRα and hLXRβ respectively.
AZ-876 is a more potent binder and activator of LXRα and LXRβ than GW3965.
AZ-876 is highly selective against FXR, RXR, TRα, TRβ etc.
AZ-876 reduces lesion area, and strongly decreases lesion area, lesion number and severity in vivo.
AZ-876 protects against pathological cardiac hypertrophy and fibrosis without lipogenic side effects in mice.
| M.Wt | 439.5704 | |
| Formula | C24H29N3O3S | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 2.6 mg/mL |
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| Chemical Name/SMILES |
3(2H)-Isothiazolone, 2-(1,1-dimethylethyl)-5-phenyl-4-[[4-(1-piperidinyl)phenyl]amino]-, 1,1-dioxide |
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1. van der Hoorn J, et al. Br J Pharmacol. 2011 Apr;162(7):1553-63.
2. Cannon MV, et al. Eur J Heart Fail. 2015 Mar;17(3):273-82.
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