Welcome to Shanghai Probechem Biochemicals Co Ltd !Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : AZD-5153
CAS No.: 1869912-39-9
Catalog No.: PC-62986Not For Human Use, Lab Use Only.
AZD-5153 is a potent, selective, bivalent and orally available BET/BRD4 bromodomain with IC50 of 5 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $148 | In stock | |
| 50 mg | $358 | In stock | |
| 100 mg | $558 | In stock | |
| 200 mg | $798 | In stock | |
| 1 g | Get quote |
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
AZD-5153 is a potent, selective, bivalent and orally available BET/BRD4 bromodomain with IC50 of 5 nM.
AZD-5153 simultaneously binds to two bromodomains in BRD4; exhibits antitumor activity in multiple xenograft models of acute myeloid leukemia, multiple myeloma, and diffuse large B cell lymphoma.
| M.Wt | 479.585 | |
| Formula | C25H33N7O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
(R)-4-(2-(4-(1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)-1,3-dimethylpiperazin-2-one |
|
1. Bradbury RH, et al. J Med Chem. 2016 Sep 8;59(17):7801-17.
2. Rhyasen GW, et al. Mol Cancer Ther. 2016 Nov;15(11):2563-2574.
3. Collins TA, et al. CPT Pharmacometrics Syst Pharmacol. 2017 Jun;6(6):357-364.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
